Elan to create research centre with Cambridge University

DUBLIN | Sun Nov 27, 2011 4:14am EST

DUBLIN (Reuters) - Elan Corp Plc has signed an agreement with Britain's Cambridge University to create a research center focused on therapies for Alzheimer's and Parkinson's, the Dublin-headquartered biotech group said on Sunday.

Elan, whose main research facility is in San Francisco, will spend $10 million over the next five years on the research center and has an option to extend the deal for another five years.

Researchers from Cambridge and Elan want to discover ways of altering the behavior of proteins that can spread neurodegenerative disorders such as Alzheimer's and Parkinson's.

"This agreement is a natural next step in the existing working relationship between our scientists in South San Francisco and scientists at the University of Cambridge," Dale Schenk, chief scientific officer at Elan, said in a statement.

"This collaborative effort complements our portfolio of programmes in neuroscience and supports the process of discovery which we believe may lead to a class of therapeutics that no one has thought possible before."

(Reporting by Carmel Crimmins; Editing by David Holmes)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/Ex_brLx3TlQ/us-elan-cambridge-idUSTRE7AQ03T20111127

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RIM, Telefonica announce NFC trial, aim to launch mobile wallet next year

RIM's NFC campaign is about to roll into Iberia, now that the BlackBerry manufacturer has announced a new partnership with Madrid-based Telefonica. This week, the two companies unveiled plans to begin testing a mobile payment and ID card system across the Spanish capital, in the hopes of launching commercial services next year. The so-called Telefonica Wallet for BlackBerry trial will involve some 350 Telefonica employees and a select group of testers within Madrid, each of whom will be able to make payments, access offices and check bank statements from their BlackBerry handsets. Telefonica's Matthew Key told Reuters that his company chose RIM to participate in the trial primarily because of the security of its BlackBerry platform, stressing the importance of earning enough consumer trust to handle sensitive personal data. No specifics yet on when or where the carrier will launch a full payment system, though Key said that Telefonica's aiming to bring it to a handful of markets in 2012.

RIM, Telefonica announce NFC trial, aim to launch mobile wallet next year originally appeared on Engadget on Fri, 25 Nov 2011 17:13:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/11/25/rim-telefonica-announce-nfc-trial-aim-to-launch-mobile-wallet/

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Playing music alters the processing of multiple sensory stimuli in the brain

ScienceDaily (Nov. 24, 2011) ? Piano practicing fine tunes the brain circuitries that temporally bind signals from our senses.

Over the years pianists develop a particularly acute sense of the temporal correlation between the movements of the piano keys and the sound of the notes played. However, they are no better than non-musicians at assessing the synchronicity of lip movements and speech. This was discovered by researchers from the Max Planck Institute for Biological Cybernetics in a comparative study on the simultaneous brain processing of stimuli from different senses by musicians and non-musicians. The researchers also used functional magnetic resonance imaging in their study to map the areas of the brain active during this process. According to their findings, in pianists, the perception of asynchronous music and hand movements triggers increased error signals in a circuit involving the cerebellum, premotor and associative areas of the brain, which is refined by piano practicing. The study shows that our sensorimotor experience influences the way in which the brain temporally links signals from different senses during perception.

In a world full of stimuli which affect all senses, the human brain constantly has to link the impressions we perceive in a way that makes sense. We learn through experience, for example, that the synchronous events that arise in a busy bar setting, such as the lip movements of a particular person and the sound of a certain voice, belong together. HweeLing Lee and research group leader Uta Noppeney from the Max Planck Institute for Biological Cybernetics in T?bingen study how the brain integrates stimuli from several senses and how the circuits in the brain change as a result of learning. In their latest study, they examined how well 18 amateur pianists were able to perceive the temporal coincidence between finger movements on the piano keys and a piece of piano music and between lip movements and spoken sentences as compared with 19 non-musicians. "For this study, we availed of the fact that the pianists specifically train in an activity, in which several sensory stimuli, that is visual and auditory information, movement and the striking of the piano keys, have to be connected," explains Uta Noppeney.

During the experiment, the finger or mouth movements were advanced or delayed in relation to the sounds heard at intervals of up to 360 milliseconds. The study participants were requested to specify when asked whether the events were synchronous or asynchronous. Using the same film and sound material and the same participants, the experiments were then repeated using functional magnetic resonance imaging (fMRI). In this case, the subjects remained passive and the machine recorded the areas of the brain that became active during the automatic perception of the synchronous and asynchronous signals.

The experiments revealed that the pianists were significantly more accurate than the non-musicians in assessing whether the finger movements on the piano and the sounds heard coincided temporally or not. "The window for the temporal integration of the stimuli in the pianists is clearly narrower than in non-musicians," says HweeLing Lee. However, the same differences were not observed in the experiments involving spoken sentences and lip movements -- both groups recorded similar performances here. In principle, asynchronicity in language and music activates the same areas in the brain. However, the fMRI scans showed that, in the experiment with the pianists, asynchronous music triggered a stronger signal in a circuit involving the left cerebellum, a premotor and associative region in the cerebral cortex than in the non-musicians.

"The processing of stimuli in the brains of the pianists points to a context-specific mechanism: as a result of their piano practice, a forward model involving the cerebellum and premotor cerebral cortex is programmed in the circuit which enables the individual to make far more precise predictions about the correct temporal sequence of the visual and auditory signals," explains Uta Noppeney. "An asynchronous stimulus triggers prediction error signal." The researchers see this as an important indication of how the brain can generally react in a flexible way to sensorimotor experience. Whether pianists would perform equally well in the assessment of violin music and whether more intensive music playing would influence language processing in the brain remain open questions. "For the next stage in the study of the processing of multiple sensory stimuli in the brain, we will have to train the participants in a specific way so that we can investigate the effects in greater detail," says Uta Noppeney.

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Journal Reference:

1. HweeLing Lee and Uta Noppeney. Long-term music training tunes how the brain temporally binds signals from multiple senses. PNAS, 2011 DOI: 10.1073/pnas.1115267108

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111124150241.htm

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Fujifilm's XS-1 bridge camera: 26x zoom, EXR sensor, ?699 in the UK (video)

Fujifilm claims it's 'reinvented' the bridge camera with the latest in its X line of premium snappers. The XS-1 is affixed to a Fujinon lens that opens up to f/2.8 and stretches all the way from 24mm to 624mm (in 35mm parlance) in an effort "cater perfectly for every photographic need" and prevent you from ever longing for the flexibility of a DSLR. It even sports a Super Macro Mode for focusing down to a rather intimate single centimeter. Behind the lens sits the same 12-megapixel EXR CMOS found in the X10, which means you get an undersized 2/3-inch sensor instead of the superior APS-C format found in the X100 and many DSLRs. Read on for more specs in the press release plus a short promo clip, and expect to see this hit British shelves in February for £699 ($1090).

Continue reading Fujifilm's XS-1 bridge camera: 26x zoom, EXR sensor, ?699 in the UK (video)

Fujifilm's XS-1 bridge camera: 26x zoom, EXR sensor, ?699 in the UK (video) originally appeared on Engadget on Thu, 24 Nov 2011 05:40:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ReMCsXXPrfE/

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Cadillac seeks to regain lost luxury turf

Rebecca Cook / Reuters

Cadillac is betting that it can regain its once-lofty standing with the launch of a series of new products that includes the big XTS sedan that made its debut earlier this month at the annual Los Angeles auto show.

By Paul A. Eisenstein

Once known as the ?standard of the world,? Cadillac has been anything but a benchmark for carmakers in recent years as imported brands such as Lexus, BMW and Mercedes-Benz have dominated the U.S. luxury market.

But now Cadillac is fighting back, betting that it can regain its once-lofty standing with the launch of a series of new products that includes the big XTS sedan that made its debut earlier this month at the annual Los Angeles auto show.

Cadillac will follow up next year with the addition of the compact ATS, and it has more new models on the drawing board.

A few years ago it might have seemed ?a stretch? for Cadillac to even imagine a comeback in the U.S., admits Don Butler, general marketing manager for the?General Motors division.

In the ?new (luxury) world old formulas don?t apply, so we had to start over? with the XTS, a premium luxury sedan that replaces two slow-selling Cadillac models, the STS and DTS, Butler said.

Caddy isn?t the only upscale domestic car brand that?s hoping to convince car show visitors in Los Angeles -- the nation's largest luxury car market -- that it can become relevant again.

Slide show: Images from the 2011 Los Angeles auto show

At this year?s show, Ford?s Lincoln division showed off updates to two of its own products, the big MKS sedan and MKT crossover. The two 2013 models get revised fascias and grilles, new wheels and modest improvements in performance and fuel economy. They?re also getting the updated version of the MyLincolnTouch systems designed to address recent criticism of the brand?s infotainment technology.

?This is truly marking the beginning? of Lincoln?s design renaissance, said Max Wolff, the brand?s chief designer, although he also hinted that the big news for Lincoln won?t be revealed until January when Detroit plays host to the North American International Auto Show -- generally thought to be the most important show in the auto show calendar.

There, the automaker plans to unveil a concept version of its next-generation Lincoln MKZ, the most popular sedan in its portfolio. The concept vehicle will introduce an all-new ?face? for the luxury brand that will abandon Lincoln?s time-tested ?waterfall grille? and move to a series of horizontal slats that are almost wing-like in appearance. The show car version will also feature an all-glass roof that will be able to open like a hard-top convertible.

The revised grille will reappear on a production version of the MKZ debuting at the New York auto show next April, although it?s not clear if the glass roof idea will be carried into production.

But the dramatic changes coming to Lincoln underscore the concerns Ford has for the Lincoln division, which has become little more than an also-ran in a market where it once vied with Cadillac for dominance.

Cadillac hasn?t stumbled quite so badly, but it has been struggling in recent years after what appeared to be a significant turnaround early in the new millennium. The maker scored big with the first generation of the compact CTS sedan, which introduced Caddy?s distinctively edgy ?art and science? design theme.

In a segment of the car market where manufacturers have traditionally opted for softer designs, the ?art and science? design ?language? was a bold standout. But after hitting a market home run with the CTS, Cadillac failed to score with the next run of offerings, like the STS, the DTS and the XLR sports coupe.

The products simply fell short of the competition in terms of interior refinement, ride and features, analysts contend.

Cadillac won?t make those mistakes again, insists Mark Reuss, president of GM?s North American operations. The goal, he insists, ?is to win in the intensely competitive luxury market, not just compete.?

Besides offering a striking exterior shape and a much more refined interior, the new XTS will introduce Cadillac?s new CUE -- an infotainment system that can be programmed using normal speech rather than requiring users to learn a complex and often confusing series of rigid commands.

These high-tech features have become a critical differentiator in the luxury market, notes Derek Kuzak, Ford?s global product development czar.

Lincoln thought it had a leg up on the competition with the MyLincolnTouch infotainment system, but, underscoring the risks of relying on high technology, the Ford luxury brand was slammed for problems with the touch-sensitive system. Indeed, influential Consumer Reports magazine lifted its sought-after ?Recommended Buy? rating from several Lincoln products this year.

The carmaker hopes to win back that endorsement with the updated MyLincolnTouch, and then show that its styling and performance are also relevant with the product offensive it is kicking off in Los Angeles this month.

But both Lincoln and Cadillac won?t have an easy time of it. Even established luxury brands such as Lexus, BMW and Mercedes are ramping up their own efforts. Lexus, in particular, is expected to be especially aggressive in the months ahead, hoping to recover the momentum it lost due to product shortages caused by the earthquake and tsunami in Japan last March.

And second-tier players such as Audi, and also Nissan?s Infiniti brand, are hoping to gain ground with their own expanding line-ups.

Then there?s the Koreans, and Hyundai in particular.

It scored an unexpected coup a few years back when its first luxury offering, the Genesis sedan, was named North American Car of the Year. The even bigger and more lavish Equus has so far this year handily beaten the company?s sales expectations, and Hyundai?s own new offering at the Los Angeles show, the big Azera, will target entry-luxury buyers who might have gone for more traditional offerings like the Lexus ES350.

Based on initial reviews, Cadillac and Lincoln are gaining visibility and credibility. But whether they can win back luxury car buyers is another matter entirely.

{"contentId":"8952609","totalVotes":"2173"}

What is your favorite luxury nameplate?

Source: http://bottomline.msnbc.msn.com/_news/2011/11/22/8952609-after-losing-ground-american-luxury-carmakers-fighting-back

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Larry Page-Run Google Shutters 7 More Projects (NewsFactor)

Google is continuing its streamlining efforts, shuttering projects that haven't panned out the way the search-engine giant hoped and folding others into other products as special features. Google's goal is to drive a simpler user experience.

In the latest round of closures, Google is getting rid of seven projects, some better known than others. Urs H?lzle, senior vice president of operations and Google Fellow, laid out the plans for each property, including Google Bookmarks Lists; Google Friend Connect; Google Gears; Google Search Timeline; Google Wave; Knol; and Renewable Energy Cheaper than Coal.

"It's good for Google to shutter projects and products that have very limited or no adoption. It helps with focus," said Greg Sterling, principal analyst at Sterling Market Intelligence. "My question, however, is what will happen to Google's vaunted 20 percent time initiative out of which many of these projects came."

Will 20 Percent Live?

A "20 percent project" is a Google philosophy that allows employees to spend one day a week working on something not in the regular job description. News reports have suggested that Google's 20 percent project will continue.

Google's jobs page for engineers notes, "We offer our engineers "20-percent time" so that they're free to work on what they're really passionate about. Google Suggest, AdSense for Content, and Orkut are among the many products of this perk."

But there have been a lot of changes at Google since co-founder Larry Page took over the CEO reins from Eric Schmidt. By his own words, Page has focused much of his energy on increasing Google's velocity and execution since he took over in April. That has meant investing in acquisitions, including $12.5 billion for Motorola, as well as dropping more than 25 projects.

Page killed Google Buzz, for example, but then again it was the project that got the search-engine giant in hot water with the Federal Trade Commission, and Google+ quickly took its place and became more popular than Buzz ever was.

Wave Goodbye

In the latest round of cuts, Google loses Bookmarks Lists, an experimental feature for sharing bookmarks and collaborating with friends. Google will also shed Friend Connect, which allows webmasters to add social features to their sites by embedding a few snippets of code.

Google Gears is going away in March. Gears is a browser extension for creating offline Web applications and stopped supporting new browsers. And Google is moving the Search Timeline graph of historical results for a query.

As of Jan. 31, Wave will become read-only; users will not be able to create new ones. On April 30 Google will turn it off completely. Knol, a project Google launched in 2007 to help improve Web content by enabling experts to collaborate on in-depth articles, is moving.

"In order to continue this work, we've been working with Solvitor and Crowd Favorite to create Annotum, an open-source scholarly authoring and publishing platform based on WordPress," H?lzle said. "Knol will work as usual until April 30, 2012, and you can download your Knols to a file and/or migrate them to WordPress.com."

Source: http://us.rd.yahoo.com/dailynews/rss/internet/*http%3A//news.yahoo.com/s/nf/20111123/tc_nf/81100

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Canned cranberries: traditional as homemade turkey (Providence Journal)

Share With Friends: | | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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Video: Quilts comfort troops

Stitch by stitch, Linda Wieck and her team of Wisconsin volunteers spread patriotism and a piece of home creating lightweight quilts for U.S. troops. NBC?s Mara Schiavocampo reports.

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Source: http://video.msnbc.msn.com/nightly-news/45294812/

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Today on New Scientist: 23 November 2011

LHC antimatter anomaly hints at new physics

The Large Hadron Collider has turned up differences in how particles of matter and antimatter decay that the reigning standard model of physics may not be able to explain

Alzheimer's damage reversed by deep brain stimulation

Brain shrinkage in people with Alzheimer's disease can be reversed in some cases - by zapping the degenerating tissue with electrical impulses

How water-bouncing balls mimic skimming stones

Watch how a special ball can ride the waves propelled by its crushed form

Nothingness: Computers are powered by holes

Digital technology wouldn't work without something missing at its heart. Richard Webb recounts the transistor's difficult birth

Our ancestors speak out after 3 million years

An unlikely experiment using plastic tubes and puffs of air is helping to recreate the first sounds uttered by our distant ancestors

Watery secret of the dinosaur death pose

Dinosaur skeletons are often found with head thrown back and tail arched. This may simply be because they have been immersed in water

Saunas could heal your mood and your heart

The little hot rooms may improve heart function and boost levels of "happiness molecule" serotonin, improving mood too

Why there is no such thing as empty space

Watch an animation that explains why a true void isn't possible according to physics

The tiny things that rule the world

An exhibition of microscopic images in Canberra, Australia unveils the bizarre and beautiful world invisible to the naked eye.

Phobos mission phones home as rescue plan is hatched

Incommunicado for the last two weeks, Russia's sample-return mission to Phobos has now finally been contacted. But can its computers be put back on track?

Nothingness: Mathematics starts with an empty set

What's inside an empty bag? Nothing - but that's something on which all mathematics is founded, says Ian Stewart

Chagos islands in sea-level rise controversy

Chagossians have been told that rapid sea-level rise will leave their former island home - now a US military base - uninhabitable in decades. Not all oceanographers agree

Older brains lack access to region for swift decisions

Brain scans show that the striatum, an area of the brain that allows for fast responses, is less well connected in the older brain

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Georgia man, 101, robbed for 2nd time in 3 months

By The Associated Press
SAVANNAH, Ga. - A 101-year-old Georgia man has been robbed of his wallet for the second time in three months, and police are seeking the public's help in their investigation.

The latest incident occurred during a burglary at Edward Vaughn's Savannah home early Sunday.

Authorities tell the Savannah Morning News? that officers responded to Vaughn's home around 2:45 a.m.

Vaughn told police that someone entered his bedroom while he was sleeping and demanded money. Police say the intruder took his wallet and left. Vaughn was not injured in the burglary incident, but did suffer minor abrasions in the earlier theft in August in which a man attacked him as he walked to his porch after getting off a bus.

Police are seeking the public's help in their investigation. Both thefts remain unsolved.

?

Source: http://usnews.msnbc.msn.com/_news/2011/11/22/8951184-101-year-old-man-robbed-for-2nd-time-in-3-months

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PC Fan hack lets you scra... scra... scratch analog audio, ah-yeah (video)

Digital DJ controllers let would-be grandmasters get up to all sorts of fancy new tricks, but if you're one of those old dogs who can't be taught, then this PC-fan-come-DJ-turntable might tickle your fancy. Connected to an old-school personal cassette via an Arduino, with a little voltage level smoothing in the mix, moving the fan "scratches" the audio, by controlling the speed of the tape player. The initial plan was to have the fan spinning with the music, like a real turntable, but as you'll know if you've ever caught your finger in one of these things, it's probably best it didn't work out. Despite its home-made charms, one final flourish is VU style LEDs for some mixer-style visual feedback. Alas, there's no built in cross-fader, so don't start work on that DMC routine just yet.

Continue reading PC Fan hack lets you scra... scra... scratch analog audio, ah-yeah (video)

PC Fan hack lets you scra... scra... scratch analog audio, ah-yeah (video) originally appeared on Engadget on Tue, 22 Nov 2011 04:29:00 EDT. Please see our terms for use of feeds.

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Missing girl's mom arrested on child abuse charges (AP)

GLENDALE, Ariz. ? Police on Monday arrested the mother of a missing 5-year-old Arizona girl on child abuse charges "directly related" to the girl, and said they don't believe they'll find the child alive.

In a news conference that offered the most detail yet about what investigators think happened to Jhessye Shockley, Glendale police said the girl's mother, Jerice Hunter, was now the investigation's "No. 1 focus."

Hunter was booked Monday at the Maricopa County jail. A sheriff's spokesman said Hunter was unable to talk to reporters because she had not yet been assigned a housing unit. She was scheduled for her first court appearance Monday night.

Hunter previously told The Associated Press she had nothing to do with Jhessye's disappearance and was highly critical of the department's investigation.

Glendale police Sgt. Brent Coombs said at the news conference that new information in the past few days led police to serve another search warrant on Hunter's Glendale apartment and arrest her Monday. He wouldn't elaborate.

He also said Hunter has not cooperated with investigators who have been trying to set up a lie-detector test with her.

Coombs added the reward offered for information leading to Jhessye has been raised to $25,000.

"I'd like to make it very clear that this is by no means the end to this investigation," Coombs said. "Our investigators will continue to work diligently to locate Jhessye. This is just a step down that investigative path towards that final conclusion."

Coombs ended the news conference when a reporter asked him directly whether investigators believe Hunter killed Jhessye, saying: "I am going to have to end those questions right now."

But Coombs said investigators don't believe Jhessye is alive.

Investigators spent Monday searching Hunter's apartment, where Jhessye was last seen Oct. 11 after Hunter said she went out for an errand and left the girl in the care of three older siblings. It was the second time police searched the home.

State Child Protective Services removed Hunter's other children, including a newborn, from the apartment last month but declined to say why. Glendale police said they had no part in the decision to remove the children.

Police previously said they had no evidence, suspects or promising leads in the case. They also said they interviewed Hunter on several occasions and had no reason to suspect her in Jhessye's disappearance.

Hunter came under scrutiny during the investigation for an October 2005 arrest with her then-husband, George Shockley, on child abuse charges in California. Hunter pleaded no contest to corporal punishment and served about four years in prison before she was released on parole in May 2010.

Hunter's oldest child, 14 at the time, told police his mother routinely beat the children.

George Shockley is a convicted sex offender and is still in a California prison. Hunter has told reporters she didn't know about his past until they were arrested and now has nothing to do with him.

Hunter's mother, Shirley Johnson, has said her daughter was a changed woman after she got out of prison and was a good mother.

Johnson did not return repeated calls for comment Monday afternoon.

Hunter was eight months pregnant when Jhessye disappeared. While still pregnant, she demonstrated at the state capitol in Phoenix, saying her daughter's case wasn't getting the attention it deserved because she is black.

At the Oct. 24 demonstration, Hunter condemned members of the media for focusing too much on her past, and said she had nothing to hide and would gladly submit to a lie-detector test.

"I have been forthcoming with law enforcement from day one. I let them turn my home into a crime scene hours after I reported that I couldn't find my daughter," she said. "They didn't find anything, but they're holding my children hostage."

She also criticized the Glendale police department's investigation.

"We feel that law enforcement is not active in finding Jhessye and that they're more active in persecuting me instead of finding out where she is," Hunter said.

In the days after Jhessye's disappearance, more than 100 officers and volunteers searched for her in pools, garbage bins and shrubs. They interviewed and searched the homes of registered sex offenders in the area, and stopped at every door to spread news about the missing girl.

Police also cordoned off an area of a local landfill where garbage from Jhessye's neighborhood would have been taken the day of and day after her disappearance, but have not searched it.

___

Follow Amanda Lee Myers on Twitter at http://twitter.com/(hash)!/AmandaLeeAP

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20111121/ap_on_re_us/us_missing_arizona_girl

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Courts put huge California water pact in limbo

SAN DIEGO (AP) ? A landmark accord that ended decades of acrimony over how Southern California gets its water is in jeopardy.

A California appeals court is considering whether to overturn a 2003 pact that created the nation's largest farm-to-city water transfer and set new rules for dividing the state's share of the Colorado River. If a lower court ruling stands, consequences could ripple to six other Western states and Mexico, which also rely on the 1,450-mile river that flows from the Rocky Mountains to the Sea of Cortez.

Farmers and environmentalists involved in the lawsuit argue the pact is deeply flawed, while water agencies say it is critical to keeping an uneasy peace on the river. A three-judge panel of the 3rd Appellate District in Sacramento will hear arguments Monday and is expected to rule within three months.

California long used more of the Colorado River than it was granted under agreements with Arizona, Colorado, Nevada, New Mexico, Utah, Wyoming and Mexico. Its overindulgence was never a big problem until Sunbelt cities like Phoenix witnessed explosive growth and other states clamored for their full share. Drought only exacerbated tensions.

Eight years of negotiations between California's warring water agencies culminated in the 2003 accord that reined the state to its limit established 80 years earlier of 4.4 million acre-feet of water a year ? enough to supply about 9 million homes. The centerpiece called for California's Imperial Valley ? a farming region that gets nearly 20 percent of the entire river ? to sell water to San Diego.

The prospect of the pact unraveling has left some of California's neighbors worried that hostilities could resume and ricochet throughout the West.

"A stable California is good for the river," said John Entsminger, senior deputy general manager for the Southern Nevada Water Authority, which supplies 2 million people in Las Vegas and surrounding areas. "Any sort of destabilization in California and their water picture would potentially be problematic for the other states."

In January 2010, Sacramento Superior Court Judge Roland Candee gutted the pact in a sweeping, 52-page ruling that said the state of California ? one of the signatories ? violated its constitution by essentially writing a blank check to restore the rapidly shrinking Salton Sea in the Imperial Valley. California's largest lake is more than 200 feet below sea level and relies on water that seeps down from nearby farms. The sale of water to San Diego further threatens the lake's future.

The judge ruled that a state law committing California to save the lake no matter the cost set a dangerous precedent for the government to pledge money to other projects it couldn't afford. The administration of former Gov. Arnold Schwarzenegger pegged the cost of saving the Salton Sea at a whopping $9 billion.

The state's dire fiscal straits offer little hope for the lake, whose rapidly receding shores are layered with dead fish.

"It's the 800-pound gorilla in the closet," said Malissa McKeith, a lawyer for Imperial Valley landowners who are challenging the pact. "If we don't fix it now, you're just going to have so much of a bigger problem in 10 years."

McKeith, like other critics of the pact, said California failed to adequately consider alternatives to the farm-to-city water transfer ? like requiring low-flow toilets ? when it recognized in the 1990s that it would have to go on a water diet.

The legal issues are highly complex, but the stakes and passions are high. The pact, which remains in effect while the case is under appeal, has already brought big changes in California.

It remains controversial in the Imperial Valley, a major grower of spinach, lettuce and other winter vegetables that has the nation's highest unemployment rate. Eight years after the Imperial Irrigation District board approved the pact in a 3-2 vote, critics say water sales to San Diego have failed to bring enough benefits to the region of 175,000 people. They worry that the Salton Sea's receding shores will worsen the region's air quality.

"There may not be enough money to take care of the liabilities of the Salton Sea, and Imperial Valley basically gets stuck with the blowing dust," said John Pierre Menvielle, a member of the local water board and a third-generation farmer who opposed the 2003 pact from the start.

The water transfers have made the San Diego area less dependent on the Metropolitan Water District of Southern California, a behemoth that serves nearly 19 million people and was virtually San Diego's only source of water in the early 1990s.

Under the pact, two Southern California canals were lined with a combined 60 miles of concrete to prevent seepage. The San Diego County Water Authority and the state of California shared the $448 million cost, with the captured water going to San Diego.

Dennis Cushman, the San Diego County Water Authority's assistant general manager, said the pact has given his agency's 3.1 million customers more reliable water sources.

The agreement "was central to giving people some certainty ? maybe not everything they hoped for or they wanted, but they got certainty over a significant portion of their water supply and their economic future," Cushman said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-11-20-California%20Water%20Wars/id-7dd6a571246e41589c4b800d1560beae

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LivingSocial goes national with Black Friday deals

NEW YORK (AP) ? Online deals service LivingSocial is going national for the holiday shopping season.

LivingSocial is best known for coupons for local restaurants, fitness classes and spas. It's unveiling two sets of deals Monday involving larger, national businesses such as Office Max, the sneaker brand Sketchers and Verizon Wireless.

LivingSocial will run special offers on Black Friday, the much-hyped shopping bonanza that takes place the day after Thanksgiving. The deals include $25 for $50 worth of Verizon devices. There's also a charity component where Toys R Us and other businesses will match $5 donations from consumers to Toys for Tots.

On Cyber Monday, the online shopping day that follows Thanksgiving weekend, LivingSocial will unveil another set of deals from online businesses such as Snapfish.

LivingSocial is based in Washington, D.C.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2011-11-21-LivingSocial-Black%20Friday/id-b004783731b84eeeb1fbb06d07ca1be4

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Kelly Clarkson at the American Music Awards: All This Jazz

Give us Kelly Clarkson standing at a microphone, simply singing, and we'd be thrilled. The original American Idol possesses that kind of sheer talent.

But the artist took to the stage at last night's American Music Awards in a shiny, beautiful dress and was flanked by a series of brass instruments, along with back-up dancers that took their cue from the early 20th century musical Newsies.

It was a fun, jazzy rendition of "Mr. Know It All" that still showcased Clarkson's incredible voice. Watch for yourself now:

Kelly Clarkson - Mr. Know It All (American Music Awards)

Other performers at the event includes Justin Bieber (HERE) and Jennifer Lopez (HERE).

Source: http://www.thehollywoodgossip.com/2011/11/kelly-clarkson-at-the-american-music-awards-all-this-jazz/

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Pope delivers spiritual road map for Africa

Faithful greet Pope Benedict XVI, as he tours, aboard his popemobile, at the stadium of Cotonou to celebrate a Holy Mass on the last day of his three-day trip to the Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

Faithful greet Pope Benedict XVI, as he tours, aboard his popemobile, at the stadium of Cotonou to celebrate a Holy Mass on the last day of his three-day trip to the Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

Women sing and wave the national flags of Togo and Benin as they wait for the arrival of Pope Benedict XVI to celebrate a Holy Mass in the stadium of Cotonou on the last day of his three-day trip to Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

Pope Benedict XVI walks to the altar to celebrate a Holy Mass in the stadium of Cotonou on the last day of his three-day trip to Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

Pope Benedict XVI sits by the altar in the stadium of Cotonou as he celebrates a Holy Mass on the last day of his three-day trip to Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

Pope Benedict XVI tours, aboard his popemobile, the stadium of Cotonou before celebrating a Holy Mass on the last day of his three-day trip to Africa's western coast country of Benin, Sunday, Nov. 20, 2011. (AP Photo/Pier Paolo Cito)

COTONOU, Benin (AP) ? Pope Benedict XVI on Sunday led tens of thousands of people in a panoply of African tongues during a Mass in Benin's national soccer stadium, wrapping up a pilgrimage where he laid out his spiritual vision for Africa.

An estimated 80,000 people bowed their heads in prayer in the arena in Benin's commercial capital of Cotonou as the pope blessed the crowd. Women who had not made it inside kneeled in the parking lot and prayed. People had formed a line outside starting at 3 a.m., said Vatican spokesman Rev. Federico Lombardi.

The Mass reflected the potential for harmony in Africa, with the liturgy delivered in at least 10 African languages and simultaneously broadcast in St. Peter's Square.

It included an acclamation in Congo's principal language, Lingala, a prayer for peace in Nigeria's Yoruba, followed by other parts of the liturgy in Ditamari, Mina, Bariba, Idaacha, and Lokpa ? all languages spoken by Benin's roughly 9 million people.

Nowhere is Catholicism growing more rapidly than on this continent of a thousand tongues which has helped breathe life into a church that has seen a steep decline in numbers of active faithful in Europe.

The pope's vision of the continent, formally delivered on Sunday to Africa's bishops in the form of an 87-page document known as a treatise, has been called a "papal road map" for Africa.

It applies church doctrine to address the continent's ills, especially the wars and conflicts caused by ethnic divisions. The strategy proposes a "sacrament of reconciliation," using the church's doctrine of forgiveness and the Christian concept of turning the other cheek in a bid to stem the cycle of retribution.

Sunday is the last day of the pope's three-day trip, the second African voyage of his papacy after his 2009 journey to Cameroon and Angola. Benin is emblematic of the growth of Catholicism, with the congregation growing by half, adding over half-a-million new converts in the past decade.

At the offertory part of the Mass, in addition to the bread and the wine, African priests in white cassocks also brought baskets full of products representing the riches of the soil and the craftsmanship of its people.

The first basket was filled with root vegetables like manioc, which is ground into flour and used to make foufou, the basic starch in the Central African diet. Another basket had palm products, a tree that serves as the symbol of a political party in neighboring Togo because every part of the tree from its oil to its fronds to its fruit can be used.

Beninois priest Rev. Benoit Odoung, who heads a Catholic college in Cotonou, said that the pope has recognized Africa's potential. The continent is poised to start sending more "reverse missionaries," African priests who travel to Europe and North America to encourage conversions at a time when congregations in the Western hemisphere are declining.

"You know, Africa is the cradle of humanity. Then when the rest of the world evolved, we trailed behind," Odoung said. "We are fundamentally religious. We have faith. And now as Christianity is declining over there, we stand to become 'the spiritual lungs of humanity,'" he said, quoting Benedict to describe Africa in the just-released document.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2011-11-20-AF-Benin-Pope/id-1e6665713b844b819968f07048cebeec

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Erwinaze Approved for Acute Lymphoblastic Leukemia (HealthDay)

FRIDAY, Nov. 18 (HealthDay News) -- Erwinaze (asparaginase Erwinia chrysanthemi) has been approved by the U.S. Food and Drug Administration to treat Acute Lymphoblastic Leukemia (ALL) among people who have developed an allergy to more standard treatments.

In this type of cancer, bone marrow produces too many infection-fighting white blood cells called lymphocytes. Typically, treatments include asparaginase and pegaspargase chemotherapy drugs. But some patients develop allergies to these medications.

Newly approved Erwinaze, injected into a muscle three times weekly, breaks down a protein building block that helps overabundant white blood cells (leukemia cells) grow. Without this protein, the leukemia cells die, the FDA said in a news release.

The safety and effectiveness of Erwinaze were evaluated in clinical studies involving 58 people. Additional safety data was harvested from a separate trial involving 843 patients, the FDA said. Observed side effects of Erwinaze included severe allergic reactions, pancreatic inflammation, high liver enzymes, abnormal bleeding or clotting, nausea and high blood sugar.

Erwinaze has been designated an orphan drug, since ALL affects fewer than 200,000 people in the United States, the FDA said.

The drug is produced by EUSA Pharma Inc., based in Langhorne, Pa.

More information

Medline Plus has more about this form of cancer.

Source: http://us.rd.yahoo.com/dailynews/rss/cancer/*http%3A//news.yahoo.com/s/hsn/20111119/hl_hsn/erwinazeapprovedforacutelymphoblasticleukemia

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President Obama sending Sec. Clinton to Burma(Myanmar)

Hillary Clinton will visit Burma(Myanmar), the first time a US Secretary of State has traveled to the southeast Asian nation in over 50 years.

U.S. President Barack Obama said on Friday he saw "flickers of progress" in Myanmar, dispatching Secretary of State Hillary Clinton for a historic visit that could draw the country out of half a century of global isolation.

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Obama, in Indonesia for a summit of Asia-Pacific leaders, said he had spoken for the first time with Myanmar democracy leader Aung San Suu Kyi who told him she supported more U.S. engagement with the country also known as Burma.

In another indication of change in Myanmar, Suu Kyi's party, the National League for Democracy, re-registered on Friday to contest a series of by-elections for vacant parliamentary seats. This follows amendments to electoral laws and brings Suu Kyi a step closer to returning to politics.

Obama said the release of political prisoners, relaxing of media restrictions and signs of legislative change in recent weeks were "the most important steps toward reform in Burma that we've seen in years".

Clinton's two-day visit from Dec. 1 would be the first by a U.S. Secretary of State since a 1962 military coup ushered in 50 years of unbroken military rule that ended in March when a nominally civilian parliament was established.

Since then, the new government has called for peace with ethnic minority groups, displayed some tolerance of criticism, suspended an unpopular Chinese-funded dam project, freed about 230 political prisoners and reached out to Suu Kyi, a Nobel Peace Prize laureate freed last year from 15 years of detention.

"We want to seize what could be a historic opportunity for progress and make it clear that if Burma continues to travel down the road of democratic reform, it can forge a new relationship with the United States of America," Obama said.

However, he cited stubborn U.S. concerns over Myanmar's stance with North Korea, human rights, treatment of ethnic minorities and the continued detention of political prisoners. U.S. officials have said these issues must be addressed before Washington can consider ending economic sanctions.

"If Burma fails to move down the path of reform, it will continue to face sanctions and isolation. But if it seizes this moment, then reconciliation can prevail," Obama said.

HUMAN RIGHTS

Many Western governments have expressed caution that more must be done for Myanmar's reforms to be considered credible. As early as Oct. 17, for instance, Derek Mitchell, special U.S. envoy for Myanmar, said there were "credible reports" of continuing human rights abuses against women and children.

Clinton is scheduled to meet Suu Kyi and visit Yangon and the capital Naypyitaw. She will "explore whether the United States can empower a positive transition in Burma and begin a new chapter between our countries", Obama said.

Myanmar welcomed the visit.

"It's a very good sign," Ko Ko Hlaing, chief political adviser to Myanmar's president, told Reuters. "I think it is a significant turn in U.S. policy towards Myanmar ... people in Myanmar will welcome, cheer Hillary Clinton because for a time in history, they have never seen a secretary of state."

With sanctions blocking Western investments, China has emerged as Myanmar's biggest ally, investing in infrastructure, hydropower dams and twin oil-and-gas pipelines to help feed southern China's growing energy needs.

Bilateral trade rose more than half last year to $4.4 billion, and China's investment in Myanmar reached $12.3 billion in 2010, according to Chinese figures, with a strong focus on natural resources and energy.

But the relationship has been strained, with a long history of resentment of China among the Burmese population and fierce public opposition to a Chinese-built dam at Myitsone that prompted Myanmar President Thein Sein to shelve the project last month, a move that stunned Beijing.

A U.S. official said the Obama administration "fully expects" China to welcome U.S. engagement with Myanmar and the United States would consult China closely on its engagement with the Southeast Asian country.

China is wary of greater U.S. influence in the region, especially in countries on its border, as Myanmar is, but the U.S. decision to engage with Myanmar should not be seen as an attempt to contain China, the U.S. official said, adding that a stable Myanmar was in China's interests.

"It's about Burma, not about China," the official said.

When Obama took office in 2009, he made reaching out to American adversaries a signature part of his foreign policy approach. That included an effort early to engage with Iran.

But the administration took a cautious approach on Myanmar because of its human rights record. Obama requested a policy review on Myanmar, paving the way for the recent diplomacy.

U.S. officials said that Obama spoke to Suu Kyi during his flight on Thursday from Australia to Bali.

The 20-minute call was the first time they had talked and he told her he had long admired her democratic struggle. They described it as a meaningful but friendly conversation in which Suu Kyi also asked about Obama's family dog.

He asked for her ideas on how to approach her country.

"She encouraged the president to make clear to Burma's leaders that the U.S. will be willing to work with them if they are in fact demonstrating that they are willing to work with the world and her," one U.S. official said.

Obama is not scheduled to have a bilateral meeting with Thein Sein but will see him in Bali at a East Asia Summit.

Southeast Asian nations endorsed Myanmar on Thursday for the chairmanship of its regional grouping in 2014, gambling that the country can stick to reforms begun this year. The United States respected that decision, a U.S. official said.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/89Tr9BvmgFA/President-Obama-sending-Sec.-Clinton-to-Burma-Myanmar

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Faster-than-light neutrinos are back in the game

Back in September, CERN dropped the improbable news about its faster-than-light neutrinos, causing eggheads worldwide to cry foul. Understandable really, as if true, a lot of what we think we know about the universe essentially falls apart. So, expect severe bouts of head-scratching once more, as a second round of experiments from the same OPERA collaborative has reported similar results. The initial experiments used a long chain of neutrinos, fired from point A to B. Skeptics claimed that this might have introduced an element of uncertainty to the results -- the new tests used much shorter blasts, meaning that if they arrived just as quickly, then this potential cause for error is scratched out. The new data still needs to undergo the usual peer review, and other possible causes for error remain. For now though, it looks like one of the main arguments against has been addressed, making the Einstein-challenging neutrinos one step closer (or is that ahead?) to re-writing the rule book.

Faster-than-light neutrinos are back in the game originally appeared on Engadget on Fri, 18 Nov 2011 22:22:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/11/18/faster-than-light-neutrinos-are-back-in-the-game/

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Scandal leaves Paterno's reputation in tatters

FILE - In this Oct. 22, 2011 file photo, Penn State coach Joe Paterno stands on the field before his team's NCAA college football game against Northwestern, in Evanston, Ill. Former Penn State coach Paterno has a treatable form of lung cancer, according to his son. Scott Paterno says in a statement provided to The Associated Press by a family representative that the 84-year-old Joe Paterno is undergoing treatment and that "his doctors are optimistic he will make a full recovery." (AP Photo/Jim Prisching, File)

FILE - In this Oct. 22, 2011 file photo, Penn State coach Joe Paterno stands on the field before his team's NCAA college football game against Northwestern, in Evanston, Ill. Former Penn State coach Paterno has a treatable form of lung cancer, according to his son. Scott Paterno says in a statement provided to The Associated Press by a family representative that the 84-year-old Joe Paterno is undergoing treatment and that "his doctors are optimistic he will make a full recovery." (AP Photo/Jim Prisching, File)

A half-century in the making, Joe Paterno's impeccable reputation was shattered in a matter of days.

He's out of a job, and his name has been scraped off the Big Ten title trophy. He's been taken to task by everyone from the president of the United States to his good friend, Bobby Bowden. Flaws in his program, once barely whispered about, are now an open topic. Although Penn State says it isn't touching Paterno's statue outside Beaver Stadium, the fact that someone even asked indicates how far his stock has fallen.

The admirable graduation rates, the players who were as good off the field as they were on, the financial support for Penn State that had nothing to do with football ? all of it has been undone by the one thing Paterno did not do. Go to the police with an abuse allegation.

"This is a scandal large enough that this is going to hang on his legacy," said Frank Fitzpatrick, a Philadelphia Inquirer columnist and author of two books on Paterno and Penn State, including the new biography, "Pride of the Lions."

"It's incredibly sad, I think. That's not to excuse what he did or say he doesn't deserve it," Fitzpatrick added. "It's still sad for a guy who, I think, really did try. ... To see it all end so unceremoniously and so ugly, it's just hard to take."

The tumult isn't over, either. Penn State said Friday that the NCAA will examine the school's handling of the child sex-abuse scandal involving former defensive coordinator Jerry Sandusky, invoking that dreaded question of "institutional control."

Later that day, Paterno's son Scott announced that his father is being treated for lung cancer. The cancer, diagnosed during a follow-up visit last weekend for a bronchial illness, is treatable, and Scott Paterno said doctors are "optimistic he will make a full recovery."

Even before the news about Paterno's health, those who admired him had started to view the 84-year-old coach as a tragic figure.

"This is difficult for everybody who knows Joe or anybody who cares about Joe," former Nebraska coach Tom Osborne, a close friend of Paterno's, said last week. "I feel bad about him and his family. I feel bad about the people who were victimized ? very bad about them."

It's been two weeks since Sandusky, Paterno's one-time heir apparent, was accused of sexually abusing eight boys in a 15-year span, setting off a child sex-abuse scandal that stunned Penn State and forever altered the image of major college football's winningest coach.

Paterno is not the target of any criminal investigation. But Penn State's board of trustees fired him Nov. 9 because it felt the coach did not go far enough in alerting authorities after then-graduate assistant Mike McQueary told Paterno he witnessed an alleged assault in March 2002.

McQueary, now Penn State's wide receivers coach, told a grand jury he saw Sandusky raping a boy of about 10 in the showers at the Penn State football building. McQueary went to Paterno, though it is not clear if he described the alleged attack in as graphic detail as he did to the grand jury. Paterno then told athletic director Tim Curley and university vice president Gary Schultz, whose responsibilities included oversight of the campus police.

No one called police.

"Did he make a mistake? Sure, he made a mistake," former Ohio State coach John Cooper said. "And is he paying the price. Absolutely and rightfully so. ... But I'm not going to forget all the good things he did."

But public opinion quickly turned against the man who for so long had been the moral compass of college athletics, the one person who could always be counted on to do the right thing in a business where so many others have gone wrong.

A day after Paterno was fired, two Pennsylvania senators announced they were rescinding their support for Paterno's nomination for the prestigious Presidential Medal of Freedom. The Big Ten announced Monday it was renaming its trophy for the conference title game, saying it would be "inappropriate" to keep Paterno's name on it.

"The trophy and its namesake are intended to be celebratory and aspirational, not controversial," Big Ten commissioner Jim Delany said.

Much of the anger stems from disillusionment, said psychologist Stan Teitelbaum, author of "Sports Heroes, Fallen Idols."

Society has a need for heroes, Teitelbaum said, and Paterno fit the bill perfectly with his "Success with Honor" philosophy. He steered Penn State clear of the tawdry scandals that sullied the reputations of high-profile programs such as Ohio State, USC and Miami, and demanded that his players conduct themselves with high character and morals.

He prized education ? his name is on a library at Penn State, not an athletic facility ? and Penn State could talk about "student-athletes" without drawing snickers. The Nittany Lions had 47 academic All-Americans under Paterno, a national-best 15 in the past five years alone. Penn State's graduation rate consistently ranks among the best in the Big Ten; in 2010, its 84 percent rate trailed only Northwestern's 95.

When Paterno was revealed as flawed ? as human ? people who had invested so much faith in him felt betrayed, Teitelbaum said.

"Joe Paterno was perceived as a very benign father figure. Father figures are supposed to protect us from the dangers of the world," Teitelbaum said. "As more and more things came out, people became more and more disappointed and disappointment turns to anger. He was supposed to have spared us."

There is an element of schadenfreude in Paterno's humbling, too.

Paterno was proud of being able to claim the moral high ground and made no attempt to hide it. He once said he wouldn't retire because he didn't want to leave coaching to the Jackie Sherrills and Barry Switzers of the world.

Switzer won three national titles at Oklahoma, but his Sooners were college football's renegades. Oklahoma was slapped with three years' probation for major recruiting violations, and five players were arrested on felony charges before Switzer stepped down in June 1989. Sherrill had brushes with the NCAA at both Texas A&M and Mississippi State.

"There were a lot of people who felt Joe was sanctimonious and holier than thou and pious when there wasn't any reason to be," Fitzpatrick said. "In that sense, that attitude set him up for a fall like this. People aren't cheerful that Joe's going through something like this but some are thinking, 'See, I told you. Even at mighty blessed Penn State.'

"But I don't think anyone expected it going wrong to this extent."

___

Follow Nancy Armour at http://www.twitter.com/nrarmour

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-11-19-FBC-Penn-State-Paterno's-Legacy/id-90e1f526c9d44bfdb5ae55c4a37aa6f9

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WildChords Arrives On The iPad With Fun Guitar Lessons In Tow

As a long-time rhythm game junkie, Ovelin's new WildChords app strikes very close to home for me. Part Guitar Hero and part instructional aid, WildChords aims to take players though the basics of playing guitar without all the theory that often scares beginners away.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/iAEttnGjB2Q/

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Ai Weiwei: Police investigating friend over porn (AP)

BEIJING ? Outspoken Chinese artist Ai Weiwei says police are investigating his assistant for allegedly spreading pornography online.

Ai said Friday that police called in videographer Zhao Zhao for questioning a day earlier.

Zhao Zhao says the police were referring to artistic, nude photos he took last year of Ai and four women.

The investigation appears to revive an accusation leveled against Ai when he was detained in April. Reports then said Ai was being investigated for tax evasion, bigamy and for spreading pornography online.

Ai was billed $2.4 million in the tax case and has recently been publicizing his efforts to fight it.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111118/ap_on_re_as/as_china_ai_weiwei

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